Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because of their antiviral and immunomodulatory properties. The recent development of direct-acting antiviral (DAA) therapy, which is associated with high rates of sustained virological response, enables a more accurate analysis of the immunological modifications following HCV eradication. We studied the dynamics of blood myeloid dendritic cells, monocytes, slan-DCs, and T lymphocytes during IFN-free and IFN-based regimens in hepatitis C virus infection.
Impact of IFN-Free and IFN-Based Treatment on Blood Myeloid Dendritic Cell, Monocyte, Slan-DC, and Activated T Lymphocyte Dynamics during HCV Infection / Vita, Serena; Zuccalà, Paola; Savinelli, Stefano; Mascia, Claudia; Rossi, Raffaella; Schiavone, Francesco; Marocco, Raffaella; Tieghi, Tiziana; Iannetta, Marco; Nijhawan, Parni; Zingaropoli, Maria Antonella; D’Ettore, Gabriella; Vullo, Vincenzo; Mastroianni, Claudio Maria; Lichtner, Miriam. - In: JOURNAL OF IMMUNOLOGY RESEARCH. - ISSN 2314-8861. - 2020:(2020), pp. 1-11. [10.1155/2020/2781350]
Impact of IFN-Free and IFN-Based Treatment on Blood Myeloid Dendritic Cell, Monocyte, Slan-DC, and Activated T Lymphocyte Dynamics during HCV Infection
Vita, Serena;Zuccalà, Paola;Savinelli, Stefano;Rossi, Raffaella;Marocco, Raffaella;Tieghi, Tiziana;Iannetta, Marco;Nijhawan, Parni;Zingaropoli, Maria Antonella;Vullo, Vincenzo;Mastroianni, Claudio Maria;Lichtner, Miriam
2020
Abstract
Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because of their antiviral and immunomodulatory properties. The recent development of direct-acting antiviral (DAA) therapy, which is associated with high rates of sustained virological response, enables a more accurate analysis of the immunological modifications following HCV eradication. We studied the dynamics of blood myeloid dendritic cells, monocytes, slan-DCs, and T lymphocytes during IFN-free and IFN-based regimens in hepatitis C virus infection.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.